Treatment of prolymphocytic leukemia

摘要: Prolymphocytic leukemia is characterized by marked splenomegaly, distinctive cellular morphologic characteristics, and a poor clinical course. Five patients with typical PL were treated systematically vincristine/prednisone, chlorambucil/prednisone, splenic irradiation, splenectomy, other chemotherapy regimens. No patient responded to vincristine/prednisone. Two four had brief responses irradiation. underwent one of whom prolonged remission. There no complete remissions. combinations value. The median survival was 33 months. Recommendations are made use chlorambucil/prednisone or irradiation as initial treatment. Splenectomy should be considered in refractory these modalities. course may more protracted than originally reported.