Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats.

摘要: Zonca, A., Ravasio, G., Gallo, M., Montesissa, C., Carli, S., Villa, R., Cagnardi, P. Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats. J. vet. Pharmacol. Therap. 35, 580–587. The pharmacokinetics the extemporaneous low doses propofol, known ‘ketofol’, frequently used for emergency procedures humans to achieve safe sedation analgesia was studied The study performed assess norketamine kinetics six female cats that received (1:1 ratio) a loading dose (2 mg/kg each, IV) followed by (10 mg/kg/h IV, 25 min length). Blood samples were collected during period up 24 h afterwards. Drug quantification achieved HPLC analysis using UV-visible detection fluorimetric propofol. pharmacokinetic parameters deduced two-compartment bolus plus model monocompartmental norketamine. Additional data derived noncompartmental analysis. Propofol quantifiable most animals until 24 8 h after end infusion, respectively. showed long elimination half-life (t1/2λ2 7.55 ± 9.86 h), whereas characterized shorter 4 ± 3.4 h) owing its rapid biotransformation into clinical significance propofol’s clearance is negligible when drug short-term low-dosage infusion. concurrent administration did not produce adverse effects although it possible exclude interference metabolism.