Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients.
作者： Tinne Laurberg , Jan Alsner , Trine Tramm , Vibeke Jensen , Christina D. Lyngholm
DOI: 10.1080/0284186X.2016.1246803
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摘要: AbstractAim: To evaluate the long-term prognostic impact of age, local treatment and intrinsic subtypes on risk local-regional recurrence (LRR) breast cancer mortality among low-risk patients.Material methods: Cohort study with prospectively collected data, balanced five-year age groups, including 514 Danish lymph node negative patients diagnosed between 1989 1998, treated mastectomy (N = 320) or breast-conserving therapy (BCT) (N = 194) without systemic treatment. Intrinsic subtype approximation was performed by combining information estrogen-, progesterone-, HER2 receptor Ki67.Results: The majority tumors had a luminal subtype: 70% Luminal-A (LumA), 16% Luminal-B (LumB), 10% Luminal-HER2 + (Lum-HER2+). distribution younger (≤45 years) older (>45 similar. no 20-year LRR risk, regardless age. A distinct pattern observ...
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