Oral anticoagulant therapy: practical aspects of management

摘要: Careful attention to the practical aspects of oral anticoagulant therapy can improve patient compliance and lessen risk bleeding complications. A variety factors for associated with have been defined should be assessed before initiating therapy. Recent investigations provided a means estimating what constitutes significant change in an individual patient's serial International Normalized Ratio (INR) by allowing combined analytic biologic variation prothrombin time determinations. Dosing adjustments warfarin sodium (Coumadin, Panwarfin, Sofarin) appropriate level INR spread over total weekly dosage optimum stable control. Elderly patients are more sensitive any given dose need significantly lower dose. Attention must paid vitamin K content diet additional factors, including other drug therapy, alcohol consumption, metabolic status. Hematuria or gastrointestinal always assessed, because chance finding clinically lesion is good, especially when has therapeutic range. Although minor prolongation without may treated watchful waiting, administration measures necessary active bleeding. Comprehensive education paramount facilitated checklist approach. well-informed provides one best defenses against