Connecting the dots: the many systemic manifestations of whipple disease.

摘要: Longman and colleagues present a case of Whipple disease with many extraintestinal manifestations, which emphasizes the importance recognizing varied clinical presentations systemic nature this disease.1 is rare, chronic, multisystemic bacterial infection caused by Tropheryma whipplei, member diverse family actinomycetes usually found in soil.2 The most prevalent individuals their 40s—60s, mean age 50 years male predominance, both are characteristics patient presented colleagues.1,3 In contrast to patient, predominantly occurs whites has rarely been described African descent or other ethnic groups. T. whipplei DNA samples waste water, gastric juices saliva without disease, fecal asymptomatic healthy donors; these findings suggest that may be ubiquitous environmental commensal organism.4–9 Although mode transmission uncertain, consistent common exposure underlying genetic susceptibility.