D-dimer and TAT measurement in patients with deep venous thrombosis: utility in diagnosis and judgement of anticoagulant treatment effectiveness.

摘要: The plasma levels of thrombin-antithrombin III-complexes (TAT) and the fibrin split product D-Dimer were measured in 39 patients with phlebographically proven acute DVT: 34 had proximal DVT, 5 calf DVT. sensitivity TAT measurements diagnosis DVT was found to be dependent on duration symptoms: 0 7 days (n = 27): elevated (greater than 120 ng/ml) 1, Latex test positive 500 6 0.88. Eight 14 7): 0.33, 0.66; specificity: D-Dimer: 0.48, test: TAT: 0.76. Calf 5) levels, negative tests 3 them normal values. Hemostatic fibrinolytic parameters also determined 13 during heparin treatment Elevated rapidly decreased after initiation anticoagulant therapy. In 2 a marked increase observed periods ineffective heparinization, documented by or only slightly prolonged thrombin clotting times. We conclude from our results that 1) EIA measurement, contrast shows very high 2) due low specificity this can used exclude thrombosis suspected 3) determination may useful for judging effect thrombotic processes.