Synthesis and cytotoxicity studies of 1-propenyl-1,3-dihydro-benzimidazol-2-one

作者: Biswadip Banerji , Sumit Kumar Pramanik

DOI: 10.1007/S12154-015-0130-8

关键词:

摘要: A heterocyclic compound 1-propenyl-1,3-dihydro-benzimidazol-2-one was synthesized by a palladium-catalyzed rearrangement reaction. Anticancer activities were confirmed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against Neura 2a (neuroblastoma cell), HEK 293 (kidney cancer) and MCF-7 (breast cell lines at low micromolar range. Furthermore, clear images from phase-contrast fluorescence microscopes confocal unambiguously confirm the cancer death. The single X-ray crystal structure of proves benzimidazolone compound.

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