Efficacy of octreotide in the prevention of complications of elective pancreatic surgery

摘要: A placebo-controlled double-blind multicentre study, with randomization into parallel groups, was performed to determine whether perioperative subcutaneous administration of octreotide 0.1 mg every 8 h reduces the rate complications specifically related pancreatic surgery. In all, 252 patients were evaluated (153 men, 99 women; mean(s.e.m.) age 53.1(0.8) years) who had or periampullary tumour other duodenal disease (157 patients) chronic pancreatitis (95) and undergoing elective resection (100 Whipple's procedure, 60 distal resection, 12 others), pancreaticojejunostomy (66) enucleation lesions (14). The proportion significantly lower in group treated than placebo (15.6 versus 29.2 per cent, P = 0.01). Octreotide thus appears reduce substantially risk Moreover, treatment acceptability high.