Regional changes in choroidal thickness associated with accommodation

摘要: Purpose. To characterize the changes occurring in choroidal thickness (ChT) across posterior pole during accommodation using enhanced-depth imaging optical coherence tomography (OCT). Methods. Forty participants (mean age 21 ± 2 years) had measures of ChT and ocular biometry taken to 0, 3, 6 diopter (D) stimuli, with Spectralis OCT Lenstar biometer. A Badal optometer cold mirror system was mounted on both instruments, allowing measurement collection while subjects viewed an external fixation target at varying accommodative demands. Results. The choroid exhibited significant thinning D stimulus subfoveal change, −5 7 μm) parafoveal regions (P < 0.001). magnitude these varied by meridian, largest seen temporal (−9 12 inferotemporal (−8 8 meridians Axial length increased +5 11 μm 3 D, +14 13 D), were weakly negatively associated (r2 = 0.114, P 0.05). Conclusions. small, but observed demand, which greatest choroid, increasing eccentricity from fovea. regional variation corresponds distribution nonvascular smooth muscle within uvea, may implicate cells as potential mechanism thins accommodation.