Examining the Pathways Between Self-Awareness and Well-Being in Mild to Moderate Alzheimer Disease

作者: Sarah Cines , Meagan Farrell , Jason Steffener , Liz Sullo , Edward Huey

DOI: 10.1016/J.JAGP.2015.05.005

关键词:

摘要: Objective To investigate the relationship between awareness of memory loss and psychological well-being in a nonclinically depressed sample participants with mild to moderate Alzheimer disease (AD). Methods Study (N = 104) enrolled through Columbia University Medical Center Pennsylvania completed clinical cognitive assessments. Participants were rated regard their degree deficits questionnaires relating well-being, including mood quality life (QOL). Mediating models used establish awareness, depression, QOL examine potential mediators distress, objective deficits, negative self-ratings. Results There was direct association but not QOL. However, there an indirect depression. Neither nor self-ratings mediated Conclusion Awareness is associated AD. does appear reflect reaction loss. Moreover, has only via mood. These results suggest that preserved have impact on overall

参考文章(53)
Stephanie Cosentino, Janet Metcalfe, Mark Cary, Jason Karlawish, Memory awareness influences everyday decision making capacity in Alzheimer's disease Alzheimers & Dementia. ,vol. 7, ,(2011) , 10.1016/J.JALZ.2011.09.145
Asmus Vogel, Erik Lykke Mortensen, Steen G. Hasselbalch, Birgitte B. Andersen, Gunhild Waldemar, Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease. International Journal of Geriatric Psychiatry. ,vol. 21, pp. 1132- 1138 ,(2006) , 10.1002/GPS.1619
Susan M. McGlynn, Daniel L. Schacter, Unawareness of deficits in neuropsychological syndromes Journal of Clinical and Experimental Neuropsychology. ,vol. 11, pp. 143- 205 ,(1989) , 10.1080/01688638908400882
Rebecca E. Ready, Brian R. Ott, Janet Grace, Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease International Journal of Geriatric Psychiatry. ,vol. 19, pp. 256- 265 ,(2004) , 10.1002/GPS.1075
SERGIO E. STARKSTEIN, ROBERT G. ROBINSON, THOMAS R. PRICE, Comparison of cortical and subcortical lesions in the production of poststroke mood disorders. Brain. ,vol. 110, pp. 1045- 1059 ,(1987) , 10.1093/BRAIN/110.4.1045
Maria Fernanda Barroso Sousa, Raquel Luiza Santos, Cynthia Arcoverde, Pedro Simões, Tatiana Belfort, Isabel Adler, Camila Leal, Marcia Cristina Nascimento Dourado, Quality of life in dementia: the role of non-cognitive factors in the ratings of people with dementia and family caregivers International Psychogeriatrics. ,vol. 25, pp. 1097- 1105 ,(2013) , 10.1017/S1041610213000410
Edward P. Feher, Glenn J. Larrabee, Thomas H. Crook, Factors Attenuating the Validity of the Geriatric Depression Scale in a Dementia Population Journal of the American Geriatrics Society. ,vol. 40, pp. 906- 909 ,(1992) , 10.1111/J.1532-5415.1992.TB01988.X
Jeffrey L. Cummings, Webster Ross, John Absher, Jeffrey Gornbein, Lida Hadjiaghai, Depressive symptoms in Alzheimer disease: assessment and determinants. Alzheimer Disease & Associated Disorders. ,vol. 9, pp. 87- 93 ,(1995) , 10.1097/00002093-199509020-00005
J.H.T. Karlawish, D. J. Casarett, B. D. James, S. X. Xie, S. Y.H. Kim, The ability of persons with Alzheimer disease (AD) to make a decision about taking an AD treatment. Neurology. ,vol. 64, pp. 1514- 1519 ,(2005) , 10.1212/01.WNL.0000160000.01742.9D
Brian R. Ott, Ginette Lafleche, William M. Whelihan, Gregg W. Buongiorno, Marilyn S. Albert, Barry S. Fogel, Impaired Awareness of Deficits in Alzheimer Disease Alzheimer Disease & Associated Disorders. ,vol. 10, pp. 68- 76 ,(1996) , 10.1097/00002093-199601020-00003