Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.

摘要: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by demyelination clinically dominates early stages relapsing-remitting MS and reversible. Once there considerable loss axons, patients enter a secondary progressive stage. Disease-modifying drugs currently in use for suppress immune system reduce relapse rates but are not effective Various animal models (mostly mouse rat) have been established proved useful studying process response to therapy. experimental autoimmune encephalomyelitis studies reviewed here showed that chronic can be induced immunization with appropriate amounts myelin oligodendrocyte glycoprotein together mycobacterium tuberculosis pertussis toxin Freund’s adjuvant. clinical manifestations were prevented or reduced treatment certain pharmacological agents given prior to, at, after peak disease, had protective effects as shown inhibiting damage neurons, axons oligodendrocytes. In cuprizone-induced toxicity studies, tested able promote remyelination increase number oligodendrocytes when administered therapeutically prophylactically. A monoclonal IgM antibody protected spinal cord preserved motor function animals inoculated Theiler’s murine virus. all these singly. combination therapy may more effective, especially using target neuroinflammation neurodegeneration, they exert synergistic actions.