Lymphokine-induced macrophage resistance to infection with Leishmania major.

摘要: Leishmania are obligately intracellular protozoan parasites whose host cell within Infected humans and experimental animals Is the macrophage. Development of an effective Immune response to these organisms presents a unique immunologic predicament: that sustains parasite viability is also central effector for induction immune responses expression cytotoxic reactions. Once inside macrophage, It protected from many humoral defense mechanisms develop during Infectious diseases. Resolution infection, then, primarily dependent upon extraordinary alterations In environment macrophage lead death parasite, or elimination itself (4,8,9). An alternative approach intervention in cycle infection with development macrophages resistant Infection parasite. Macrophages undergoing vigorous infectious agent ingest fewer obligate facultatively Intracellular pathogens vitro than uninfected mice (8,14). fact, this decreased uptake parasites, which we call “resistance infection”, has been observed activated obtained Mycobacterium bovis strain BCG, as well L. donovanI-infected were resolving systemic disease (5,14).