The Revolutionary Roads to Study Cell–Cell Interactions in 3D In Vitro Pancreatic Cancer Models
作者： Bruno Sainz , Giuseppe Gigli , Giuseppe Gigli , Riccardo Rizzo , Loretta L. del Mercato
关键词:
摘要: Pancreatic cancer, the fourth most common cancer worldwide, shows a highly unsuccessful therapeutic response. In last 10 years, neither important advancements nor new strategies have significantly impacted patient survival, highlighting need to pursue avenues for drug development discovery and design. Advanced cellular models, resembling as much possible original in vivo tumor environment, may be more successful predicting efficacy of future anti-cancer candidates clinical trials. this review, we discuss novel bioengineered platforms anticancer pancreatic from traditional two-dimensional models innovative three-dimensional ones.
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