Comparison of TSH Levels with Liquid Formulation Versus Tablet Formulations of Levothyroxine in the Treatment of Adult Hypothyroidism
作者： Davide Brancato , Alessandro Scorsone , Gabriella Saura , Lidia Ferrara , Anna Di Noto
DOI: 10.4158/EP13418.OR
关键词:
摘要: Objective: A great number of factors can interfere with levothyroxine (LT4) tablet absorption, leading to increased serum thyroid-stimulating hormone (TSH) levels and, accordingly, LT4 requirements. oral solution (LT4-OS) is a novel formulation pharmacokinetics profile different from those tablets. The aim this study was retrospectively evaluate whether TSH were decreased after switching adult hypothyroid patients the LT-OS.Methods: We evaluated 53 outpatients on replacement therapy (consumed within 1 hour before breakfast) who switched tablets LT4-OS without changing daily dose. compared preswitch (TSH1) level 60 90 days switch (TSH2) and examined clinical differences between whose did not drop switch.Results: After switch, median value 3.04 (interquartile range [IQR] 1.75-6.80) 2.30 (IQR 1.21-3.81) μIU/m...
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