Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.
作者： Xiaojun Wang , George Minasov , Brian K. Shoichet
DOI: 10.1016/S0022-2836(02)00400-X
关键词:
摘要: Pressured by antibiotic use, resistance enzymes have been evolving new activities. Does such evolution have a cost? To investigate this question at the molecular level, clinically …
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