Antimalarial Transmission-Blocking Interventions: Past, Present, and Future.

摘要: Malaria remains a major global health challenge. Appropriate use of current antimalarial tools has reduced the disease burden, but morbidity and mortality remain unacceptably high. It is widely accepted that, to achieve long-term control/eradication, it will be necessary interventions that inhibit transmission parasites mosquitoes - these are termed transmission-blocking (TBIs). This article aims outline rationale for development TBIs, with focus on drugs (parasite-derived) vaccines. We describe summarise status each intervention classes attempt identify future requirements in development, challenges establishing method within an integrated malarial control programme future.