Evaluating the impact of real-time multicriteria optimizers integrated with interactive plan navigation tools for HDR brachytherapy.

摘要: Abstract Purpose Currently in high-dose-rate (HDR) brachytherapy planning, manual fine-tuning of an objective function is a common practice. Furthermore, automated planning approaches such as multicriteria optimization (MCO) are still limited to the automatic generation single treatment plan. This study aims quantify efficiency gains when using graphics processing unit–based MCO (gMCO) algorithm combined with novel graphical user interface (gMCO-GUI) that integrates efficient and interactive plan navigation tools. Methods Materials The gMCO was used generate 1000 Pareto optimal plans per case for 379 prostate cases. gMCO-GUI developed allow through all plans. parameter selection tools directly navigation. quality each evaluated based on Radiation Treatment Oncology Group 0924 protocol more stringent institutional (INSTp). allows real-time time display dose–volume histogram indices, curves, isodose lines during Results Over cases, fraction valid target coverage greater than 95% 90.8%, compared 66.0% clinical INSTp 81.8%, 62.3% average compute deliverable 12.5 s, including full computation 3D dose distributions. Conclusions Combining resulted simultaneous both efficiency.