Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction.
作者： Nicholas Svitek , Penny A. Rudd , Karola Obojes , Stéphane Pillet , Veronika von Messling
DOI: 10.1016/J.VIROL.2008.02.035
关键词:
摘要: Even though ferrets are one of the principal animal models for influenza pathogenesis, lack suitable immunological reagents has so far limited their use in host response studies. Using recently established real-time PCR assays a panel ferret cytokines, we analyzed local immune to human isolates H1N1 and H3N2 subtypes that varied virulence. We observed severity clinical signs correlated with gross- histopathological changes lungs was subtype-independent. Strains causing mild disease were associated strong rapid innate upregulation IL-8, while severe infections characterized by lesser induction type I II interferons IL-6 upregulation. These findings suggest more virulent strains may interfere efficiently at early stages.
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