Maturity-onset diabetes mellitus — Toward a physiologically appropriate management

摘要: "Eumetabolic" therapies of diabetes are defined as those which promote and potentiate a normal physiological pattern insulin activity--in contrast to the less subtle effects exogenous or sulfonylureas. Effective eumetabolic therapy would provide better metabolic control reduce risk secondary complications, be more convenient administer, especially appropriate for preventive use in early stages diabetes. Possible components include: aspirin, potentiator glucose-stimulated secretion; GTF, directly enhance efficacy insulin; weight loss, exercise, fasting, help tissue resistance mitochondrial "metavitamins", optimize oxidative disposal excess substrate; high-fiber, low-fat diet, appears superior traditional diabetic diets promoter glucose tolerance. Following prolonged fast, obese diabetics show substantial improvement most parameters function--an effect is some degree independent loss; long-term remission may possible if benefits therapeutic fasting conserved by measures.