Future Human Bone Research in Space

摘要: Skylab crewmembers demonstrated negative calcium (Ca) balance reaching about -300 mg/day by flight day 84. Limited bone density (BMD) measurements documented that was not lost equally from all parts of the skeleton. Subsequent BMD studies during long duration Russian flights regional extent loss. These mean losses in spine, femur neck, trochanter, and pelvis 1%-1.6% with large differences between individuals as well sites a given individual. available data indicate postflight recovery occurred some individuals, but may require several years for complete restoration. Long bedrest showed similar pattern loss (-180 mg/day) spaceflight. During bedrest, resorption markers were elevated, formation unchanged, 1,25 vitamin D (VitD) absorption decreased, serum ionized Ca increased. Although this information is good beginning, additional spaceflight research needed to assess architectural subregional changes, elucidate mechanisms, develop efficient effective countermeasures. Space poses number unique problems encountered ground-based laboratory research. Therefore, researchers contemplating human need consider related their experimental design.