Differences in the efficacy of S-1 monotherapy according to histological type in pretreated patients with advanced non-small cell lung cancer.
作者： Yasushi Hisamatsu , Haruyasu Murakami , Hiroaki Akamatsu , Madoka Kimura , Keita Mori
关键词:
摘要: Background S-1 is a novel antimetabolic agent that inhibits thymidylate synthase. The expression of synthase higher in squamous (Sq) non-small cell lung cancer (NSCLC) than non-Sq NSCLC. aim this retrospective study was to assess the efficacy S-1 monotherapy for advanced NSCLC according histological subtype. Methods We reviewed clinical records patients with treated as second- or third-line therapy between May 2005 and July 2012 at Shizuoka Cancer Center. Results A total 71 were included study. Patient characteristics similar Sq (n = 15) 56) groups, except regard gender smoking status. overall response rates 0% (95% confidence interval [CI] 0–17%) 11% CI 3–19%) (P 0.33). For NSCLC, median progression-free survival times 2.1 2.8 months 0.02), respectively, 6.1 10.1 0.01), respectively. Conclusion S-1 may be more effective those
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