Epigenetic Control of Lymphocyte Differentiation

摘要: Lymphocyte differentiation from haematopoietic stem cells (HSCs) is a multi-step process in which lineage fate choices are made at crucial branch points. Plasticity of common precursors evidenced by presence transcriptionally favourable chromatin structures several lineage-specific loci, making them poised for further priming and regulation. Down the tree, interplay between networks transcription factors epigenetic modifications gradually decreases multipotency ability increases compromise within particular lineage. The maintenance cell-specific phenotype result sustained gene expression programs resulting activation repression lineage-discrepant loci. peripheral functional specialisation lymphocytes requires plasticity, to allow onto short term effectors cells, or long memory circulating resident cells. Impaired deregulated unbalanced production certain subsets underlies pathogenesis lymphoproliferation, autoimmunity possibly immunodeficiency. Understanding mechanisms governing lymphocyte would future therapeutic interventions prevent aberrant deviations promote beneficial cell populations.