Structural and mechanistic studies of Trypanosoma brucei ornithine decarboxylase
作者： Margaret A. Phillips
DOI: 10.1007/978-3-0348-8397-9_54
关键词:
摘要: Ornithine decarboxylase (ODC) is a pyridoxal-5’-phosphate (PLP)-dependent enzyme that catalyzes the first committed step in biosynthesis of polyamines. The polyamines are ubiquitous cell growth factors and biosynthetic enzymes have been interest as potential drug targets for treatment proliferative diseases. X-ray structural analysis eukaryotic ODCs shows homodimer with two identical active sites formed at dimer interface. A number site residues identified similar mechanistic roles to analogous other PLP-dependent enzymes, whereas others provide basis reaction substrate specificity required by ODC.
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sci-hub.st 参考文章(18)
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