Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome

摘要: To investigate whether neuromuscular blocking agents (NMBA) exert beneficial effects in acute respiratory distress syndrome (ARDS) by reason of their action on mechanics, particularly transpulmonary pressures (P L). A prospective randomised controlled study patients with moderate to severe ARDS within 48 h the onset ARDS. All were monitored means an oesophageal catheter and followed up for 48 h. Moderate into two groups according they given a 48-h continuous infusion cisatracurium besylate or not (control group). Severe did undergo randomisation all received per protocol. The changes during period oxygenation including inspiratory expiratory P L driving pressure, assessed compared. Delta (∆P L) was defined as minus L. Thirty included, 24 6 NMBA associated improvement both ARDS, accompanied decrease plateau pressure total positive end-expiratory pressure. mean higher group receiving than control group. In contrast, there no change either ∆P related administration. could at least part, limiting efforts.