Variations in Disrupted-in-Schizophrenia 1 gene modulate long-term longitudinal differences in cortical thickness in patients with a first-episode of psychosis

摘要: Schizophrenia patients typically present a widespread bilateral cortical thinning from the early stages of illness. However, there is controversy whether this reduction in thickness (CT) static or progressive over evolution disorder. Disrupted-in-Schizophrenia 1 (DISC1) one main candidates genes for schizophrenia, as it has been found associated to illness, and several endophenotypes disorder including structural brain differences. This gene known be involved neurodevelopment maturation processes. We therefore hypothesized that variations modulate different progressions CT psychosis. Seventy-nine Caucasian drug-naive experiencing first episode non-affective psychosis were genotyped rs6675281 (Leu607Phe) rs821616 (Ser704Cys) SNPs DISC1 gene. Brain MRIs carried out at baseline 3 years after initiating treatment. Other clinical socio-demographic variables recorded rule possible confounding effects. Patients homozygous Leu allele SNP had significant (p < 0.05) descend 3-years period, while those carrying Phe presented an increase CT. When combining two we synergic effect on progression, presenting Leu607 +Ser704 more pronounced thinning. In conclusion, may longitudinal changes suffering