Effect of systemic injection of heterogenous and homogenous opioids on peripheral cellular immune response in rats with bone cancer pain: A comparative study.

作者: Jun-Ying Du , Yi Liang , Jun-Fan Fang , Yong-Liang Jiang , Xiao-Mei Shao

DOI: 10.3892/ETM.2016.3647

关键词:

摘要: Exogenous and endogenous opioids have been shown to modulate the immune system. Morphine-induced immunosuppression has investigated extensively. However, immune-regulating function of opioid peptides is unclear. The present study aimed evaluate difference in effects on cellular between recombinant rat β-endorphin (β-EP; 50 µg/kg) plant source morphine (10 mg/kg) via intraperitoneal injection treatment a model bone cancer pain. Walker 256 cells were injected into tibial cavity establish pain model. paw withdrawal thresholds body weights measured prior surgery, at 6 days after following 1, 3,6 8 treatments. spleen harvested for detection T cell proliferation, natural killer (NK) cytotoxicity, relative quantities subtypes (CD3+, CD4+ CD8+ cells). Plasma levels interleukin-2 (IL-2) also determined. It was found that single or multiple treatments with β-EP (a homogenous peptide) heterogenous opioid) had good analgesic pain, while analgesia provided by stronger than β-EP. Treatment 3, times increased weight gain effect it. With regard immunomodulatory functions, proliferation NK subtypes, but no secretion. decreased subtypes. These data indicate from different sources vivo. A small dose peptide exhibited positive (analgesia enhancement) results provide experimental evidence supporting exploitation human

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