A facilitation action of reserpine on the central nervous system.

摘要: Summary1. Data are presented to show a facilitation action of reserpine on the central nervous system. The drug hastens onset maximal tonic extensor seizures in mice receiving intravenous Metrazol or caffeine (but not strychnine). It lowers convulsive seizure threshold electrical stimuli and antagonizes anticonvulsant Dilantin. 2. Some possible mechanisms certain clinical implications this property suggested.