Coronary artery disease and dyslipidemia within Europe: genetic variants in lipid transport gene loci in German subjects with premature coronary artery disease
作者： A. Kay , W. März , M.M. Hoffmann , Q. Zhang , L.l. Masana
DOI: 10.1016/S1567-5688(01)00003-4
关键词:
摘要: Fifteen polymorphisms in six lipid transport genes were studied a German population for relationships with dyslipidemia and coronary artery disease (CAD), to investigate possible genetic basis the marked differences mortality rates from heart within Europe. In other populations these have all been associated CAD or phenotypes known predispose CAD. The apoAI PstI polymorphism (P<0.005) lipoprotein lipase Ser(447)-Ter mutation plasma triglyceride concentrations. Additionally, (P<0.05), apoB XbaI (P<0.05) apoE cholesterol However, none of allele frequencies related presence, absence, disease. Associations between five representing four gene loci demonstrated this population. It is that predisposition Germany involves particular selection polymorphic loci, which are different those identified European countries.
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