Sitagliptin (DPP-4 Inhibitor)-induced Rheumatoid Arthritis in Type 2 Diabetes Mellitus: A Case Report
作者： Kazuki Yokota , Naoya Igaki
DOI: 10.2169/INTERNALMEDICINE.51.7592
关键词:
摘要: A dipeptidyl peptidase (DPP)-4 inhibitor, commonly used to treat patients with type 2 diabetes, has caused concern because of immune system side effects. We report a 48-year-old woman diabetes who was diagnosed rheumatoid arthritis (RA) after continued polyarthritis and an increase in factor up 86 IU/mL three months treatment sitagliptin, DPP-4 inhibitor. The shared epitope (SE)-containing human leukocyte antigen (HLA)-DRB1 alleles, which are important predisposing factors for RA, were positive. RA might have been triggered by sitagliptin due condition.
japanlinkcenter.org参考文章(17)
Pius Loetscher, Bernhard Moser, Homing chemokines in rheumatoid arthritis. Arthritis Research & Therapy. ,vol. 4, pp. 233- 236 ,(2002) , 10.1186/AR412
C. MUSCAT, A. BERTOTTO, E. AGEA, O. BISTONI, R. ERCOLANI, R. TOGNELLINI, F. SPINOZZI, M. CESAROTTI, R. GERLI, Expression and functional role of 1F7 (CD26) antigen on peripheral blood and synovial fluid T cells in rheumatoid arthritis patients Clinical and Experimental Immunology. ,vol. 98, pp. 252- 256 ,(2008) , 10.1111/J.1365-2249.1994.TB06134.X
Tom W. J. Huizinga, Christopher I. Amos, Annette H. M. van der Helm-van Mil, Wei Chen, Floris A. van Gaalen, Damini Jawaheer, Geziena M. T. Schreuder, Mark Wener, Ferdinand C. Breedveld, Naila Ahmad, Raymond F. Lum, Rene R. P. de Vries, Peter K. Gregersen, Rene E. M. Toes, Lindsey A. Criswell, Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis & Rheumatism. ,vol. 52, pp. 3433- 3438 ,(2005) , 10.1002/ART.21385
Annette HM van der Helm-van Mil, Tom WJ Huizinga, Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Research & Therapy. ,vol. 10, pp. 205- 205 ,(2008) , 10.1186/AR2384
Nathalie Busso, Nicolai Wagtmann, Christian Herling, Veronique Chobaz-Péclat, Angelika Bischof-Delaloye, Alexander So, Eric Grouzmann, Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. American Journal of Pathology. ,vol. 166, pp. 433- 442 ,(2005) , 10.1016/S0002-9440(10)62266-3
Annette H. M. van der Helm-van Mil, Kirsten N. Verpoort, Ferdinand C. Breedveld, Tom W. J. Huizinga, René E. M. Toes, René R. P. de Vries, The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis & Rheumatism. ,vol. 54, pp. 1117- 1121 ,(2006) , 10.1002/ART.21739
Oscar Cordero, Francisco Salgado, Antonio Mera-Varela, Montserrat Nogueira, Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis. Rheumatology International. ,vol. 21, pp. 69- 74 ,(2001) , 10.1007/S002960100134
Patricia Irigoyen, Annette T. Lee, Mark H. Wener, Wentian Li, Marlena Kern, Franak Batliwalla, Raymond F. Lum, Elena Massarotti, Michael Weisman, Claire Bombardier, Elaine F. Remmers, Daniel L. Kastner, Michael F. Seldin, Lindsey A. Criswell, Peter K. Gregersen, Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis : Contrasting effects of HLA-DR3 and the shared epitope alleles Arthritis & Rheumatism. ,vol. 52, pp. 3813- 3818 ,(2005) , 10.1002/ART.21419
A. König, V. Krenn, A. Toksoy, N. Gerhard, R. Gillitzer, Mig, GROα and RANTES messenger RNA expression in lining layer, infiltrates and different leucocyte populations of synovial tissue from patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis Virchows Archiv. ,vol. 436, pp. 449- 458 ,(2000) , 10.1007/S004280050472
Caroline Ospelt, Joachim C. Mertens, Astrid Jüngel, Fabia Brentano, Hanna Maciejewska-Rodriguez, Lars C. Huber, Hossein Hemmatazad, Thomas Wüest, Alexander Knuth, Renate E. Gay, Beat A. Michel, Steffen Gay, Christoph Renner, Stefan Bauer, Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts Arthritis & Rheumatism. ,vol. 62, pp. 1224- 1235 ,(2010) , 10.1002/ART.27395