Slow Synaptic Inhibition in Nucleus HVc of the Adult Zebra Finch

摘要: Nervous systems process information over a broad range of time scales and thus need corresponding cellular mechanisms spanning that range. In the avian song system, long integration times are likely necessary to auditory feedback bird’s own vocalizations. For example, in nucleus HVc, center contains both premotor neurons is thought act as gateway for into slow inhibitory appear play an important role processing information. These long-lasting processes include potentials shape selectivity vocalization-induced inhibition responses lasting several seconds. To investigate possible these processes, we have made intracellular recordings from HVc slices adult zebra finch brains stimulated extracellularly within HVc. A brief, high-frequency train stimuli (50 pulses at 100 Hz) could elicit hyperpolarizing response lasted 2–20 sec. The hyperpolarization (SH) still be elicited presence glutamate receptor blockers, suggesting it does not require polysynaptic excitation. Three major components contribute this activity-induced SH: GABAB receptor-mediated IPSP, afterhyperpolarization requiring action but Ca2+ influx, neurotransmitter which remain unidentified. three events well placed observed after singing during learning.