αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target.

摘要: αB-crystallin is a widely expressed member of the small heat shock protein family that protects cells from stress by its dual function as molecular chaperone to preserve proteostasis and cell death antagonist negatively regulates components conserved apoptotic machinery. Deregulated expression occurs in broad array solid tumors has been linked tumor progression poor clinical outcomes. This review will focus on new insights into mechanisms which oncogenes, oxidative stress, matrix detachment other microenvironmental stressors deregulate expression. We also accumulating evidence pointing an essential role for multi-step metastatic cascade whereby colonize distant organs circumventing multitude barriers migration survival. Finally, we evaluate emerging strategies therapeutically target and/or interacting proteins selectively activate apoptosis derail effort improve outcomes patients with disease.