Arylsulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
作者： Thomas Rueckle , Marco Biamonte , Russell J. Thomas , Jean-Pierre Gotteland
DOI:
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摘要: The present invention relates to sulfonamide derivatives of formula (I) notably for use as pharmaceutically active compounds, well pharmaceutical formulations containing such derivatives. Said are useful in the treatment neuronal disorders, autoimmune diseases, cancer and cardiovascular diseases. Furthermore, said efficient modulators JNK pathway, they particular selective inhibitors JNK2 -3. is furthermore related novel methods their preparation. Formula IAr1 a substituted or unsubstituted aryl heteroaryl group; X O S, preferably O; Ar2 arylene heteroarylene group;R?1 R2? independently selected from group consisting hydrogen C?1?-C6-alkyl group.
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