Use of beta-catenin in the expansion of stem and progenitor cells
作者： Tannishtha Reya , Irving L. Weissman , Roeland Nusse
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摘要: Mammalian progenitor or stem cells are expanded in vitro by increasing the levels of β-catenin cell. The substantially maintain their original phenotype including ability to give rise multiple types differentiated cells. intracellular may be manipulated providing exogenous protein cell, introduction into cell a genetic construct encoding β-catenin. wild-type stabilized mutant form protein. Preferably long term culture medium lacks stromal and cytokines.
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