Production of a canine beta cell line from an immature pancreas

作者: Paul Czernichow

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摘要: The present invention relates to a method for preparing commercial scale quantities of canine functional beta cells and the establishment cell lines from immature pancreatic tissues. It also diagnosis using tumours or derived thereof. comprises sub-transplantation procedure enrich graft in proliferating cells, allowing generating Beta lines. Such express, produce secrete insulin upon glucose stimulation.

参考文章(37)
Carlos F. Barbas, Phage Display: A Laboratory Manual ,(2004)
Teruna Siahaan, Lisa A. Stehno-Bittel, Cory Berkland, Karthik Ramachandran, Templated islet cells and small islet cell clusters for diabetes treatment ,(2012)
Eckhard Lammert, Irena Konstantinova, Screening method for anti-diabetic compounds ,(2008)
Raphael Scharfmann, Paul Czernichow, Philippe Ravassard, Production of a human beta cell line from an early post natal pancreas ,(2012)
Emily J. Shields, Carol J. Lam, Aaron R. Cox, Matthew M. Rankin, Thomas J. Van Winkle, Rebecka S. Hess, Jake A. Kushner, Extreme Beta-Cell Deficiency in Pancreata of Dogs with Canine Diabetes PLOS ONE. ,vol. 10, pp. e0129809- ,(2015) , 10.1371/JOURNAL.PONE.0129809
K. L. Hawkins, B. A. Summers, F. P. Kuhajda, C. A. Smith, Immunocytochemistry of normal pancreatic islets and spontaneous islet cell tumors in dogs. Veterinary Pathology. ,vol. 24, pp. 170- 179 ,(1987) , 10.1177/030098588702400211
Dean H. Betts, Ian C. Tobias, Canine Pluripotent Stem Cells: Are They Ready for Clinical Applications? Frontiers in Veterinary Science. ,vol. 2, pp. 41- 41 ,(2015) , 10.3389/FVETS.2015.00041
Ramon Llull, Marc H. Hedrick, Adam J. Katz, J. William Futrell, Hermann Peter Lorenz, Prosper Benhaim, Min Zhu, Adipose-derived stem cells and lattices ,(2000)