Dispersions for the formulation of slightly or poorly soluble agents
作者： Rainer H. Muller
DOI:
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摘要: The invention provides a dispersion having an oily phase, aqueous in the form of oil-in-water emulsion or water-in-oil emulsion, and at least one active ingredient that is only slightly with difficulty soluble phase phase. free from toxicologically dangerous organic solvents. contains dissolved quantity greater than which results additively its maximum solubility prior to forming emulsion.
lens.org 参考文章(15)
G. J. Vanderheiden, A. C. Fairchild, G. R. Jago, Construction of a Laboratory Press for Use with the French Pressure Cell Applied Microbiology. ,vol. 19, pp. 875- 877 ,(1970) , 10.1128/AM.19.5.875-877.1970
Herbert A. Lieberman, Martin M. Rieger, Gilbert S. Banker, Pharmaceutical Dosage Forms: Disperse Systems ,(1988)
Klaus-Jürgen Dr. Steffens, Peter Christian Prof. Dr. Schmidt, Paul Heinz Prof. Dr. Dr. List, Harald Perschbacher, Hans Peter Dr. Kraemer, Hans Harald Dr. Sedlacek, Pharmaceutical formulation and process for its preparation ,(1987)
Robert J. Kaufman, Ralph W. Fuhrhop, Thomas J. Richard, Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same ,(1995)
S. Venkataram, W.M. Awni, K. Jordan, Y.E. Rahman, Pharmacokinetics of two Alternative Dosage Forms for Cyclosporine: Liposomes and Intralipid Journal of Pharmaceutical Sciences. ,vol. 79, pp. 216- 219 ,(1990) , 10.1002/JPS.2600790307
Pei Kan, Zhi-Beng Chen, Chau-Jen Lee, I-Ming Chu, Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system. Journal of Controlled Release. ,vol. 58, pp. 271- 278 ,(1999) , 10.1016/S0168-3659(98)00164-3
Denis Caillot, Olivier Casasnovas, Eric Solary, Pascal Chavanet, Bernard Bonnotte, Guillaume Reny, Fahrad Entezam, Jose Lopez, Alain Bonnin, Henri Guy, Efficacy and tolerance of an amphotericin B lipid (Intralipid) emulsion in the treatment of candidaemia in neutropenic patients. Journal of Antimicrobial Chemotherapy. ,vol. 31, pp. 161- 169 ,(1993) , 10.1093/JAC/31.1.161
Ann M Kaukonen, Ilkka Kilpeläinen, Jukka-Pekka Mannermaa, Water-soluble β-cyclodextrins in paediatric oral solutions of spironolactone: solubilization and stability of spironolactone in solutions of β-cyclodextrin derivatives International Journal of Pharmaceutics. ,vol. 159, pp. 159- 170 ,(1997) , 10.1016/S0378-5173(97)00280-9
Alison G Floyd, Top ten considerations in the development of parenteral emulsions. Pharmaceutical Science & Technology Today. ,vol. 2, pp. 134- 143 ,(1999) , 10.1016/S1461-5347(99)00141-8
P. Chavanet, M. Duong, M. Buisson, H. Hamel, C. Dubois, A. Bonnin, H. Portier, In-vivo activity and tolerance of conventional formulation versus fat emulsion formulation of amphotericin B in experimental disseminated candidiasis in neutropenic rabbits. Journal of Antimicrobial Chemotherapy. ,vol. 39, pp. 427- 430 ,(1997) , 10.1093/JAC/39.3.427