Visualization of Biological Material by the Use of Coated Contrast Agents
作者： Kajsa Uvdal , Oskar Axelsson
DOI:
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摘要: A method for visualizing biological material, preferably by MRI, comprising the steps of: (i) bringing a population of coated nanoparticles into contact with said each which comprises a) metal oxide transition metal, being paramagnetic and lanthanide (+III) such as gadolinium (+III), b) coating covering surface core particle, (ii) recording image; wherein is hydrophilic silane layer located next to particle one or more different groups an organic group R silane- siloxane linkage where R' hydrophobic spacer B, O oxygen directly binding ion oxide, c) C carbon also part B. composition visualization methods manufacture particles are disclosed. Visualization includes imaging MR, CT, X-ray, near IR fluorescence, PET, microscopying etc largest advantages accomplished in-vivo imaging.
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