Gdf-9/bmp-15 modulators for the treatment of bone disorders
作者： Yogendra P. Kharode , Ashok Bapat , Gregory S Kopf , Vargheese M. Chennathukuzhi , Frederick J. Bex
DOI:
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摘要: The invention provides methods for treating or preventing bone degenerative disorders. disorders treated prevented include, example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imperfecta, and associated with chronic renal hyperparathyroidism, long-term use of corticosteroids. disclosed therapeutic include administering to a mammal an inhibitor GDF-9 BMP-15 in amount effective to: (1 ) treat prevent disorder; (2) slow deterioration; (3) restore lost bone; (4) stimulate new formation; and/or (5) maintain mass quality. also agonist disorder characterized by increased density mass.
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