Deciphering the state of immune silence in fatal COVID-19 patients.

摘要: Since the beginning of the SARS-CoV-2 pandemic, COVID-19 appeared as a unique disease with unconventional tissue and systemic immune features. Here we show signature associated severity by integrating single-cell RNA-seq analysis from blood samples broncho-alveolar lavage fluids clinical, immunological functional ex vivo data. This is characterized lung accumulation naive lymphoid cells expansion activation myeloid cells. Myeloid-driven suppression hallmark evolution, highlighting arginase-1 expression regulatory features monocytes. Monocyte-dependent neutrophil-dependent loss fatal clinical outcome in severe patients. Additionally, our shows CXCR6+ effector memory T cell subset better prognosis patients COVID-19. In summary, COVID-19-induced dysregulation impairment establish condition 'immune silence' critical