DNA mismatch repair and the DNA damage response.
作者： Zhongdao Li , Alexander H. Pearlman , Peggy Hsieh
DOI: 10.1016/J.DNAREP.2015.11.019
关键词:
摘要: This review discusses the role of DNA mismatch repair (MMR) in damage response (DDR) that triggers cell cycle arrest and, some cases, apoptosis. Although focus is on findings from mammalian cells, much has been learned studies other organisms including bacteria and yeast [1,2]. MMR promotes a DDR mediated by key signaling kinase, ATM Rad3-related (ATR), to various types encountered widely used chemotherapy regimes. An introduction ATR reveals its immense complexity highlights many biological mechanistic questions remain. Recent future directions are highlighted.
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