Regulation of TGFβ/SMAD signaling by long non-coding RNAs in different cancers: Dark Knight in the Castle of molecular oncology
作者： Rukset Attar , Ammad Ahmad Farooqi , Aima Adylova , Ishmuratova Margarita Yulaevna , Auyezova Ardak Mukhanbetzhanovna
DOI: 10.1016/J.NCRNA.2020.12.003
关键词:
摘要: Abstract One of the complex themes in recent years has been multi-layered regulation TGFβ signaling cancer cells. TGFβ/SMAD pathway is a highly complicated web proteins which work spatio-temporally to regulate multiple steps carcinogenesis. shown dualistically progression. Therefore, behaves as “double-edged sword” molecular oncology. Accordingly, because oncogenic and tumor suppressor long non-coding RNAs (LncRNAs). In this review, we have summarized most breakthroughs our understanding related by lncRNAs. We comprehensively analyzed how different lncRNAs positively negatively cancers. gathered missing pieces an incomplete jig-saw puzzle lncRNA-interactome ranging from “sponge effects” mechanistic modulation
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