Relative frequency and risk factors for long-term opioid therapy following surgery and trauma among adults: a systematic review protocol

摘要: When patients have been on opioid therapy for more than 90 days, half of them continue using opioids years later. Knowing that long-term consumption could lead to harmful side effects including misuse, abuse, and addiction, it is important understand the risks transitioning prolonged reduce its occurrence. Perioperative trauma contexts are ideal models commonly used study such transition. Long-term use might be associated with transformation acute pain chronic, which an example a risk factor. The objectives this knowledge synthesis examine relative frequency factors among who undergone surgical procedure or experienced trauma. proposed methodology based Preferred ReportIng Systematic Reviews Meta-Analysis Protocols (PRISMA-P) statements conduct systematic review meta-analysis, MOOSE Guidelines Meta-Analyses Observational Studies, Cochrane Handbook Review Interventions. A literature search will include multiple databases: Central, EMBASE, MEDLINE, PsycINFO, CINHAL, PubMed, grey literature. We identify studies related beyond acute/subacute control after surgery Two reviewers screen all retrieved articles eligibility data extraction then critically appraise identified studies. compile narrative results meta-analysis when feasible. As available permits, we perform subgroup analysis vulnerable populations. This contribute prevention harm reduction strategies prescription by identifying leading unwarranted therapy. identification common help orient further research management as well offer key therapeutic targets development prevent use. protocol was registered in PROSPERO March 2, 2018; registration number CRD42012018089907 .