[The background of drug-resistant tuberculosis patients on the basis of the annual report database for 2007-2009 in Japan].

摘要: In this study, the background of drug-resistant tuberculosis (TB) patients in Japan was analyzed using annual report database for 2007-2009. The results drug susceptibility test 15,425 who were diagnosed with pulmonary TB between 2007 and 2009 obtained analyzed. chi-square independence parameters (i.e., sex, age, nationality, etc.) conducted. Logistic regression analysis performed variables (20s, 30s, 40s ..., new treatment, retreatment, that statistically significant by test. risk multi-drug resistance (MDR) among underwent retreatment significantly high (odds ratio = 11.3, 95% CI: 7.7-16.6, p < 0.001, reference treatment), MDR foreigners had entered within last 5 years also 9.5, 4.6-19.4, Japanese). Moreover, logistic previously undergone treatment. higher treated after 1970 than those before 1970. Especially, 1990-1999 extremely 20.8, 5.7-75.0, 1970). 3.8, 1.1-13.2, 0.036). Similar to MDR, one or more drugs 2.2, 1.9-2.6, 0.001) 1.8, 1.3-2.5, 0.001); however, their lower MDR. addition, odds ratios age groups younger 80 over obtained. They 2.1 (95% 1.5-2.9) 0-29 years, 2.2 1.6-3.0) 30-39 1.7-3.0) 40-49 1.6-2.8) 50-59 1.9 1.4-2.5) 60-69 1.5 1.2-1.8) 70-79 years. With respect have recently Japan, usage RFP poor adherence entry from high-prevalence countries suspected. Regarding generational differences drugs, it suspected most people been infected bacilli distant past, anti-TB available, when not yet emerged. However, generations become susceptible because being widely used they born, prevalent world.