Quantitation of acetaminophen and salicylic acid in plasma using capillary electrophoresis without sample pretreatment. Improvement of precision.

摘要: Abstract Capillary electrophoresis has become one of the most attractive techniques in analysis biological samples. Pharmaceuticals human plasma can easily be determined on uncoated fused-silica capillaries without any sample pretreatment. Intra- and inter-day precision values about 1–2% R.S.D. (n=20) 2–3% (n>80) respectively are obtained using a sodium dodecyl sulfate-containing borate buffer, pH 10 acetonitrile as between-run rinsing reagent. This method is highly robust, no breakdowns current or capillary blockings were observed for several weeks. The general applicability demonstrated model drugs. effectiveness other procedures including enzyme-containing solutions, different organic solvents hydrofluoric acid discussed.