Derivation of striatal neurons from human stem cells

摘要: Huntington's disease cell therapy is for the moment only therapeutic approach this devastating neurodegenerative disorder that has demonstrated significant and long-lasting functional benefits in patient. Logistical biological difficulties associated with use of human fetal tissue however dramatically reduce number patients eligible to therapy. During past decade, exploration alternative cellular sources, conducted parallel clinical trials, gradually put forward pluripotent stem cells as prime candidate Protocols differentiation such into therapeutically relevant striatal neuron precursors require thorough understanding molecular determinant controls development anterior ventral part forebrain from which striatum arises. Key secreted molecules play pivotal roles these regions mice have been successfully used direct specification neural derivatives cells. Assessment potential resulting grafts made progress last 4 years. The proof principle embryonic can achieve some degrees repair a mouse model now established. As other diseases Parkinson's disease, recent developments raised hopes cell-based disease.