Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm.

摘要: Anti-Sm antibodies are highly specific markers for the diagnosis of systemic lupus erythematosus (SLE). This specificity suggests that immunoregulation these autoantibodies would reflect fundamental immune abnormalities in this disorder. As a clue to immunoregulation, we have investigated isotype distribution anti-Sm by enzyme-linked immunosorbent assays. We found response is markedly restricted IgG1 heavy chain isotype. On other hand, light reflects normal serum, while isoelectric focusing analysis fails show an oligoclonal pattern. The related specificity, anti-ribonucleoprotein, also IgG1, SLE-specific antibody anti-double-stranded DNA mostly with lesser contribution IgG3. These results suggest antinuclear strongly associated SLE produced T cell-dependent response, probably driven antigen. several autoantigens may be quite similar.