Characterization of clinical CSF dynamics and neural axis compliance using the pressure-volume index: I. The normal pressure-volume index

摘要: The pressure-volume index (PVI) technique was used to measure neural axis compliance, cerebrospinal fluid (CSF) formation (If), and CSF absorption (Ro) in 23 children 7 adults, all free from intracranial masses, who were undergoing diagnostic or therapeutic procedures. Using bolus manipulation of CSF, If 0.36 +/- 0.08 ml/min Ro 2.8 0.8 mm Hg/ml/min both adults children. PVI, as a compliance volume buffering capacity, 25.9 3.7 ml for the adults. Measured PVI varied 8.2 30.1 but correlated well (r = 0.93) with predicted based on estimates spinal volumes obtained external measurements. This study provides normal reference data humans assessing hydrodynamics using pathological settings.