Development of a Non-Invasive Dynamic Pulmonary Function Monitor

摘要: Characterizing the complexity of airflow limitation in diagnosing and assessing disease severity asthma, COPD, cystic fibrosis, other respiratory diseases can help guide clinicians toward most appropriate treatments. Current technologies allow obstructive lung to be measured with about 5%−10% precision. A noninvasive dynamic pulmonary function monitor (DPFM) quantify ventilation inhomogeneities, such as those originating partially blocked or constricted small airways, 1% precision if inert gas concentrations accurately precisely over three four decades sensitivity. We have studied linearity a commercially available mass spectrometer, sampling exhaled by mechanical analog, mimicking multibreath washout measurement. The root mean square deviation concentration for each “breath,” compared expected value purely exponential decay, is found 1.1% concentration. corresponding overall impairment, specific measure inhomogeneity, 0.2%, which indicates that were inhomogeneities observed, impairment could