FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1.

摘要: F-box and WD repeat domain-containing 7 (FBW7) has been characterized as a tumor suppressor, its mutation or decreased expression observed in many types of human cancers. Our recent studies have uncovered that pancreatic cancer, the KRAS FBW7 through phosphorylation subsequent ubiquitination. Moreover, inhibited aerobic glycolysis cancer via induction thioredoxin-interacting protein (TXNIP), mitochondrial localized suppressor. The roles anti-apoptosis drug resistance proteosomal degradation myeloid cell leukemia-1 (MCL-1), which is an anti-apoptotic factor reported. However, role chemotherapeutic to gemcitabine seldom In present study, we demonstrated overexpression cells rendered increased sensitivity gemcitabine. Mechanistically, promoted upregulation equilibrative nucleoside transporter 1 (ENT1) at level rather than transcriptional level. depth analysis ENT1 could be by lysosome inhibition. Taken together, our results target for improving therapeutic efficacy ENT1.