Evaluation of Normal Prostate Tissue, Chronic Prostatitis, and Prostate Cancer by Quantitative Perfusion Analysis Using a Dynamic Contrast-Enhanced Inversion-Prepared Dual-Contrast Gradient Echo Sequence

摘要: Objective: To quantify independent pharmacokinetic parameters for differentiation of prostate pathology. Material and Methods: Twenty-seven patients with biopsy-proven cancer (PSA: 1.4 –16.1 ng/mL) underwent magnetic resonance imaging a new dynamic contrast-enhanced, inversionprepared dual-contrast gradient echo sequence (T1/T2*-weighted, 1.65 seconds temporal resolution) using combined endorectal/body phased-array coil at 1.5 Tesla. Perfusion, blood volume, mean transit time, delay, dispersion were calculated sequential 3-compartment model. Twenty-three prostatectomy. For histologic correlation pathologist mapped areas normal tissue, chronic prostatitis, (total 63 areas) on sections corresponding to the planes. Results: Compared low-grade (Gleason score 6) only showed higher perfusion (1.01 mL/cm 3 / min vs. 0.26 /min, P 0.050), whereas high-grade (1.21 /min 0.001), volume (1.44% 0.95%, 0.005), shorter time (3.55 4.40 seconds, 0.019), delay (10.15 13.36 0.015), smaller (8.56 12.11 0.020). High-grade than prostatitis 0.90 0.041). Chronic (0.90 0.006), (1.53% 0.046), (11.42 (10.49 0.020) tissue. There no statistically significant differences between or prostatitis. Conclusion: The investigated, especially perfusion, allow in situ tissue from