Long‐term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures
作者： Dominique Debanne , Beat H. Gähwiler , Scott M. Thompson
DOI: 10.1111/J.1469-7793.1998.237BU.X
关键词:
摘要: 1. Long-term potentiation (LTP) and depression (LTD) were investigated at synapses formed by pairs of monosynaptically connected CA3 pyramidal cells in rat hippocampal slice cultures. 2. An N-methyl-D-aspartate (NMDA) receptor-mediated component the unitary EPSP, elicited resting membrane potential response to single action potentials an individual cell, could be isolated pharmacologically. 3. Associative LTP was induced when presynaptic repeatedly paired with 240 ms postsynaptic depolarizing pulses that evoked five twelve or near peak EPSP. induction prevented NMDA receptor antagonist. 4. LTD a certain delay after either potentials. The time window within which activity had occur for dependent on amount depolarization. if pre- occurred synchronously. 5. Homosynaptic 3 Hz tetanization neuron min blocked 6. Depotentiation produced stimulation protocols elicit homosynaptic associative LTD. 7. Recurrent excitatory between display depression. sign change synaptic strength is function relative timing
sci-hub.se 参考文章(41)
Donald O. Hebb, The organization of behavior Neurocomputing: foundations of research. pp. 43- 54 ,(1988)
A Mason, A Nicoll, K Stratford, Synaptic transmission between individual pyramidal neurons of the rat visual cortex in vitro The Journal of Neuroscience. ,vol. 11, pp. 72- 84 ,(1991) , 10.1523/JNEUROSCI.11-01-00072.1991
EL Bienenstock, LN Cooper, PW Munro, Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex The Journal of Neuroscience. ,vol. 2, pp. 32- 48 ,(1982) , 10.1523/JNEUROSCI.02-01-00032.1982
D. Jaffe, D. Johnston, Induction of long-term potentiation at hippocampal mossy-fiber synapses follows a hebbian rule Journal of Neurophysiology. ,vol. 64, pp. 948- 960 ,(1990) , 10.1152/JN.1990.64.3.948
Yves Frégnac, Daniel Shulz, Simon Thorpe, Elie Bienenstock, None, A cellular analogue of visual cortical plasticity Nature. ,vol. 333, pp. 367- 370 ,(1988) , 10.1038/333367A0
D. Debanne, B. H. Gahwiler, S. M. Thompson, Cooperative interactions in the induction of long-term potentiation and depression of synaptic excitation between hippocampal CA3-CA1 cell pairs in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11225- 11230 ,(1996) , 10.1073/PNAS.93.20.11225
R. Zalutsky, R. Nicoll, Comparison of two forms of long-term potentiation in single hippocampal neurons Science. ,vol. 248, pp. 1619- 1624 ,(1990) , 10.1126/SCIENCE.2114039
K. Kobayashi, T. Manabe, T. Takahashi, Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse. Science. ,vol. 273, pp. 648- 650 ,(1996) , 10.1126/SCIENCE.273.5275.648
Robert U. Muller, Matt Stead, Hippocampal place cells connected by Hebbian synapses can solve spatial problems. Hippocampus. ,vol. 6, pp. 709- 719 ,(1996) , 10.1002/(SICI)1098-1063(1996)6:6<709::AID-HIPO13>3.0.CO;2-4
H Markram, J Lübke, M Frotscher, A Roth, B Sakmann, Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. The Journal of Physiology. ,vol. 500, pp. 409- 440 ,(1997) , 10.1113/JPHYSIOL.1997.SP022031